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Article

Physiologically based pharmacokinetic modeling to predict exposures in healthy Japanese subjects with different CYP2C19 phenotypes: Esomeprazole case study .

International journal of clinical pharmacology and therapeutics - 1 Jan 2020

Higashimori Mitsuo, Shimada Hitoshi, Ichikawa Katsuomi, Zhou Diansong

Abstract excerpt

PURPOSE: The objective of this study was to improve the predictive performance of cytochrome P450 (CYP) 2C19 substrates in Japanese subjects using physiologically based pharmacokinetic (PBPK) modeling. MATERIALS AND METHODS: Esomeprazole, a CYP2C19 substrate, was selected as a test compound, and the Simcyp simulator was used for pharmacokinetic prediction. The compound file of esomeprazole model developed in...

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PMID: 31657713
DOI: 10.5414/CP203488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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