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Article

TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population.

Biochemical genetics - 1 Aug 2024

Aflouk Youssef, Saoud Hana, Inoubli Oumaima, Yacoub Saloua, Zaafrane Ferid, Gaha Lotfi, Bel Hadj Jrad Besma

Abstract excerpt

Immune dysregulation has been widely described in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BD). Particularly, TLR4-altered activation was proposed as one of the underlying processes of psychosis onset. Since TLR4 activation was altered by T399I and D299G polymorphisms, we hypothesized that those variants could present common genetic factors of SCZ and BD. A total of 293 healthy volunteers...

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PMID: 37947916
DOI: 10.1007/s10528-023-10553-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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