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Article

Genetic Predisposition of TLR 1 and TLR 6 Polymorphisms to Schizophrenia Onset and Prediction of Treatment Response.

Biochemical genetics - 1 Apr 2026

Aflouk Youssef, Kenz Amira, Saoud Hana, Yacoub Saloua, Zaafrane Ferid, Gaha Lotfi, Bel Hadj Jrad Besma

Abstract excerpt

Immunological dysregulation was described as one of the underlying mechanisms of schizophrenia (SCZ). Indeed, altered inflammation triggered by toll-like receptors (TLR) complexes TLR2-1 and TLR2-6 has gained attention in SCZ pathophysiology and treatment response. However, the genetic contribution of TLR1 and TLR6 remains unclear. Therefore, the present study aims to explore the possible association of TLR1 and...

Topics

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Case-Control Studies
TG gene
TLR6 gene
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Toll-Like Receptor 1

Toll-Like Receptor 6

Source

Identifiers

PMID: 40360845
DOI: 10.1007/s10528-025-11127-x

Genes

TLR1
TLR6
TG
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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