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Functional Proteomics Characterization of the Role of SPRYD7 in Colorectal Cancer Progression and Metastasis.

Cells - 31 Oct 2023

Montero-Calle Ana, Jiménez de Ocaña Sofía, Benavente-Naranjo Ruth, Rejas-González Raquel, Bartolomé Rubén A, Martínez-Useros Javier, Sanz Rodrigo, Dziaková Jana, Fernández-Aceñero María Jesús, Mendiola Marta, Casal José Ignacio, Peláez-García Alberto, Barderas Rodrigo

Abstract excerpt

SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified via spatial proteomics as being upregulated in highly metastatic-to-liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly metastatic KM12C CRC cells. Here, we aimed to analyze SPRYD7's role in CRC via functional proteomics. Through immunohistochemistry, the overexpression of SPRYD7 was observed to be...

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Identifiers

PMID: 37947626
DOI: 10.3390/cells12212548
PMCID: PMC10648221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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