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Article

A prototype-augmented graph representation learning framework for identifying brain disorder-associated genes and facilitating drug repurposing.

PLoS computational biology - 1 May 2026

Li Jiafang, Li Yifei, Lin Siying, Rao Jiahua, Zhao Huiying

Abstract excerpt

Many genetic loci were identified as associated with neuropsychiatric disorders and neurodegenerative disorders by Genome-wide association studies (GWAS). How these loci impact these diseases is unclear. Advances in deep-learning approaches and multi-omics data have the potential to link GWAS findings with disease mechanisms. Here, we proposed the Multi-omics Graph Transformer Network (MOGT), a semi-supervised...

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PMID: 42213730
DOI: 10.1371/journal.pcbi.1014323
PMCID: PMC13221074

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