Article
mTOR eosinophilic renal cell carcinoma: a distinctive tumor characterized by mTOR mutation, loss of chromosome 1, cathepsin-K expression, and response to target therapy.
Virchows Archiv : an international journal of pathology - 1 Dec 2023
Caliò Anna, Marletta Stefano, Settanni Giulio, Rizzo Mimma, Gobbo Stefano, Pedron Serena, Stefanizzi Lavinia, Munari Enrico, Brunelli Matteo, Marcolini Lisa, Pesci Anna, Fratoni Stefano, Pierconti Francesco, Raspollini Maria Rosaria, Marchetti Antonio, Doglioni Claudio, Amin Mahul B, Porta Camillo, Martignoni Guido
Abstract excerpt
In the spectrum of oncocytic renal neoplasms, a subset of tumors with high-grade-appearing histologic features harboring pathogenic mutations in mammalian target of rapamycin (mTOR) and hitherto clinical indolent behavior has been described. Three cases (2F,1 M) with histologically documented metastases (lymph node, skull, and liver) were retrieved and extensively investigated by immunohistochemistry, FISH, and...
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