Recurrent mTOR pathway alterations in renal cell carcinoma with hemangioblastoma-like features: A multi-institutional study of 9 cases with expanding morphologic spectrum.

doi:10.1007/s00428-025-04362-5

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Article

Recurrent mTOR pathway alterations in renal cell carcinoma with hemangioblastoma-like features: A multi-institutional study of 9 cases with expanding morphologic spectrum.

Virchows Archiv : an international journal of pathology - 1 Sept 2026

Zhao Ming, Yang Xiaoqun, Yin Xiaona, Ma Tianshi, Jin Hongtao, Xu Jiayun, Zhang Huizhi, Wang Suying

Abstract excerpt

Renal hemangioblastoma (HB) is a rare extra-central nervous system mesenchymal neoplasm molecularly defined by recurrent mTOR pathway alterations and lacking VHL abnormalities, distinct from its central nervous system counterpart. While rare renal cell carcinomas (RCCs) exhibiting HB-like features have been documented, their clinicopathological spectrum, biological behavior, and molecular underpinnings remain...

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Topics

Humans
Carcinoma, Renal Cell
Hemangioblastoma
Kidney Neoplasms
TOR Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Middle Aged

Biomarkers, Tumor

Aged

Adult

Signal Transduction

Immunohistochemistry

Mutation

Source

Open in PubMed

Identifiers

PMID: 41286520
DOI: 10.1007/s00428-025-04362-5

Genes

VHL
GPNMB
MTOR
PAX8
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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