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Article

TSC/MTOR-mutated eosinophilic renal tumors are a distinct entity that is CK7+/CK20-/vimentin-: a validation study.

Human pathology - 1 Sept 2021

Tjota Melissa Y, Wanjari Pankhuri, Segal Jeremy, Antic Tatjana

Abstract excerpt

Unclassified renal cell carcinoma (RCC) accounts for ∼10% of renal tumors, and the most common histologic finding in these cases is eosinophilic cytoplasm. We previously demonstrated that a subset of eosinophilic renal tumors with heterogeneous morphology and immunohistochemical (IHC) staining harbored pathogenic mutations in tuberous sclerosis complex (TSC) or mammalian target of rapamycin (MTOR) as the primary...

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Identifiers

PMID: 33352195
DOI: 10.1016/j.humpath.2020.12.006

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