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Article

Somatic Bi-allelic Loss of TSC Genes in Eosinophilic Solid and Cystic Renal Cell Carcinoma.

European urology - 1 Oct 2018

Mehra Rohit, Vats Pankaj, Cao Xuhong, Su Fengyun, Lee Nicole D, Lonigro Robert, Premkumar Kumpati, Trpkov Kiril, McKenney Jesse K, Dhanasekaran Saravana M, Chinnaiyan Arul M

Abstract excerpt

Renal cell carcinomas (RCC) with overlapping histomorphologic features poses diagnostic challenges. This is exemplified in RCCs with eosinophilic cytoplasm that include eosinophilic solid and cystic RCC (ESC RCC), RCCs in germline aberrations of tuberous sclerosis complex (TSC) genes mutated (TSC RCC) individuals, and other RCC subtypes. We used next-generation sequencing (NGS) technology to molecularly profile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29941307
DOI: 10.1016/j.eururo.2018.06.007
PMCID: PMC6390848

Genes

TSC1
TSC2

Provenance

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