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Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies

7 Nov 2023

Abstract excerpt

Transplacental antibody transfer is crucially important in shaping neonatal immunity. Recently, prenatal maternal immunization has been employed to boost pathogen-specific immunoglobulin G (IgG) transfer to the fetus. Multiple factors have been implicated in antibody transfer, but how these key regulators work together to elicit selective transfer is pertinent to engineering vaccines for mothers to optimally...

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PMID: 37934786
DOI: 10.1371/journal.pcbi.1011109

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