Reduced ambiguity and improved interpretability of bacterial genome-wide associations using gene-cluster-centric k-mers.

Abstract excerpt

The wide adoption of bacterial genome sequencing and encoding both core and accessory genome variation using k-mers has allowed bacterial genome-wide association studies (GWAS) to identify genetic variants associated with relevant phenotypes such as those linked to infection. Significant limitations still remain because of k-mers being duplicated across gene clusters and as far as the interpretation of...

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