Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the ribosomal P complex leads to stress-induced autophagy.

Autophagy - 1 Jan 2015

Artero-Castro Ana, Perez-Alea Mileidys, Feliciano Andrea, Leal Jose A, Genestar Mónica, Castellvi Josep, Peg Vicente, Ramón Y Cajal Santiago, Lleonart Matilde E L

Abstract excerpt

The human ribosomal P complex, which consists of the acidic ribosomal P proteins RPLP0, RPLP1, and RPLP2 (RPLP proteins), recruits translational factors, facilitating protein synthesis. Recently, we showed that overexpression of RPLP1 immortalizes primary cells and contributes to transformation. Moreover, RPLP proteins are overexpressed in human cancer, with the highest incidence in breast carcinomas. It is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Multiprotein Complexes

Share to Reactive Oxygen Species

Share to Ribosomal Proteins

Share to RNA, Small Interfering

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 26176264
DOI: 10.1080/15548627.2015.1063764
PMCID: PMC4590587

Genes

RPLP1
RPLP0
RPLP2
ATF4
ATF6
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the ribosomal P complex leads to stress-induced autophagy.PMID 26176264Read ↗

Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescenceSemantic proximity Read ↗

mTORC1 senses stresses: Coupling stress to proteostasisSemantic proximity Read ↗

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growthSemantic proximity Read ↗

Mitochondrial ribosomal proteins: potential targets for cancer prognosis and therapySemantic proximity Read ↗

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistanceSemantic proximity Read ↗

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21 waf1/cip1 levels in a p53-independent mannerSemantic proximity Read ↗

p53 induces a survival transcriptional response after nucleolar stressSemantic proximity Read ↗

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress.Semantic proximity Read ↗

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cellsSemantic proximity Read ↗

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.Semantic proximity Read ↗

Endoplasmic reticulum proteostasis: a key checkpoint in cancerSemantic proximity Read ↗

A new <scp>PICT</scp>ure of nucleolar stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.