Article

Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment

2020-07-06

Abstract excerpt

<h4>Background: </h4> Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of malignancies with a nearly equal incidence and mortality rates in patients. Pancreatic stellate cells (PSCs) are critical players in PDAC microenvironment to promote the aggressiveness and pathogenesis of the disease. Dysregulation of microRNAs (miRNAs) have been shown to play a significant role in progression of P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fe8c64d-e340-5f82-8d6d-f2fec6d32768
DOI: 10.21203/rs.3.rs-22558/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironmentDOI 10.21203/rs.3.rs-22558/v3Read

miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2Semantic proximity Read

In Silico RNA-Seq Analysis Reveals Key Transcriptomic Signatures in Pancreatic CancerSemantic proximity Read

Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic GenesSemantic proximity Read

The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesisSemantic proximity Read

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancerSemantic proximity Read

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype.Semantic proximity Read

RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancerSemantic proximity Read

The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinomaSemantic proximity Read

Single cell RNA-seq analysis with a systems biology approach to recognize important differentially expressed genes in pancreatic ductal adenocarcinoma compared to adjacent non-cancerous samples by targeting pancreatic endothelial cellsSemantic proximity Read

The stellate cancer-associated fibroblast in pancreatic ductal adenocarcinoma : its role in chemoresistanceSemantic proximity Read

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor.Semantic proximity Read

Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic CancerSemantic proximity Read