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Article

[Assessment of CYP2D6 activity as a form of optimizing antidepressant therapy].

Psychiatria polska - 1 Jan 2000

Szewczuk-Bogusławska Monika, Grzesiak Magdalena, Beszłej Jan Aleksander, Kiejna Andrzej

Abstract excerpt

Cytochrome 2D6 catalyzes oxidation processes of many antidepressants (TCAs, SSRIs, maprotyline, mianserine, nefazodon, trazodon, venlafaxine). CYP2D6 is characterized by genetically determined polymorphism which may lead to serious clinical consequences. Based on CYP2D6 activity four phenotypes are distinguished: poor metabolism (PM), intermediate (IM), extensive (normal) EM and ultrarapid (UM). In case of PM and...

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PMID: 15779673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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