Article
Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.
Therapie - 1 Jan 2000
Perault M C, Bouquet S, Bertschy G, Vandel S, Chakroun R, Guibert S, Vandel B
Abstract excerpt
The correlation between debrisoquine and dextromethorphan oxidation polymorphism was studied in 16 depressed in-patients. There was a close correlation between both phenotypes (r = 0.81 p less than 0.0017). During a treatment with amitriptyline during two weeks there was no significant modification of the dextromethorphan polymorphism. In the same way, the association of amitriptyline and toloxatone during two...
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