Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.

Article

Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.

Therapie - 1 Jan 2000

Perault M C, Bouquet S, Bertschy G, Vandel S, Chakroun R, Guibert S, Vandel B

Abstract excerpt

The correlation between debrisoquine and dextromethorphan oxidation polymorphism was studied in 16 depressed in-patients. There was a close correlation between both phenotypes (r = 0.81 p less than 0.0017). During a treatment with amitriptyline during two weeks there was no significant modificati...

Topics

Adult
Aged
Amitriptyline
Debrisoquin
Depressive Disorder
Dextromethorphan
Female
Humans
Male
Middle Aged
Monoamine Oxidase Inhibitors
Oxazoles
Oxazolidinones
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.