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Article

The effect of immunomodulatory drugs on aortic stenosis: a Mendelian randomisation analysis.

Scientific reports - 1 Nov 2023

Ciofani Jonathan L, Han Daniel, Nazarzadeh Milad, Allahwala Usaid K, De Maria Giovanni Luigi, Banning Adrian P, Bhindi Ravinay, Rahimi Kazem

Abstract excerpt

There are currently no approved pharmacological treatment options for aortic stenosis (AS), and there are limited identified drug targets for this chronic condition. It remains unclear whether inflammation plays a role in AS pathogenesis and whether immunomodulation could become a therapeutic target. We evaluated the potentially causal association between inflammation and AS by investigating the genetically...

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Identifiers

PMID: 37914784
DOI: 10.1038/s41598-023-44387-x
PMCID: PMC10620428

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