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Article

Sex-specific genetic architecture of blood pressure.

Nature medicine - 1 Mar 2024

Yang Min-Lee, Xu Chang, Gupte Trisha, Hoffmann Thomas J, Iribarren Carlos, Zhou Xiang, Ganesh Santhi K

Abstract excerpt

The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using the UK Biobank resource, identifying 1,346 previously reported and 29 new BP trait-associated loci. Among associated loci, 412 were female-specific (Pfemale ≤ 5 × 10-8; Pmale > 5 × 10-8) and 142 were...

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PMID: 38459180
DOI: 10.1038/s41591-024-02858-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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