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Article

Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation.

DNA and cell biology - 1 Nov 2005

Bjørkhaug Lise, Bratland André, Njølstad Pål Rasmus, Molven Anders

Abstract excerpt

Hepatocyte nuclear factor-1alpha (HNF-1alpha) is a homeodomain-containing transcription factor regulating the expression of liver and pancreas-specific genes. Mutations in the HNF-1alpha-encoding gene TCF1 cause maturity-onset diabetes of the young, type 3 (MODY3). These mutations may affect nuclear import or reduce the ability of HNF-1alpha to stimulate transcription. We performed a functional dissection of...

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Identifiers

PMID: 16274290
DOI: 10.1089/dna.2005.24.661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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