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Article

Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver.

Hepatology communications - 1 Jul 2022

Morrison Joshua K, DeRossi Charles, Alter Isaac L, Nayar Shikha, Giri Mamta, Zhang Chi, Cho Judy H, Chu Jaime

Abstract excerpt

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single-cell transcriptome of the adult zebrafish liver to determine its utility as a model for studying liver fibrosis. We used single-cell RNA sequencing (scRNA-seq) of adult...

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PMID: 35315595
DOI: 10.1002/hep4.1930
PMCID: PMC9234649

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