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Article

An in vitro model and the underlying pathways of sinonasal inverted papilloma development.

Scientific reports - 27 Oct 2023

Nukpook Thawaree, Kiyono Tohru, Ekalaksananan Tipaya, Kasemsiri Pornthep, Teeramatwanich Watchareporn, Vatanasapt Patravoot, Chaiwiriyakul Surachat, Nakahara Tomomi, Pientong Chamsai

Abstract excerpt

Recently, the specific association between Sinonasal inverted papilloma (SIP) and EGFR exon 20 mutations has been reported. To investigate the link between specific EGFR mutations and SIP development, we established organotypic raft culture system using nasal polyp-derived immortalized NP2 (iNP2) cells expressing EGFR exon 20 mutants or an exon 19 mutant, and SIP-derived iIP4 cells harboring P772_H773insPYNP...

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PMID: 37891239
DOI: 10.1038/s41598-023-45585-3
PMCID: PMC10611779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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