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Article

Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study.

eLife - 26 Oct 2023

Jiang Lan, Liu Ge, Oeser Annette, Ihegword Andrea, Dickson Alyson L, Daniel Laura L, Hung Adriana M, Cox Nancy J, Chung Cecilia P, Wei Wei-Qi, Stein C Michael, Feng Qiping

Abstract excerpt

Background: Two risk variants in the apolipoprotein L1 gene (APOL1) have been associated with increased susceptibility to sepsis in Black patients. However, it remains unclear whether APOL1 high-risk genotypes are associated with occurrence of either sepsis or sepsis-related phenotypes in patients hospitalized with infections, independent of their association with pre-existing severe renal disease. Methods: A...

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Source

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Identifiers

PMID: 37882666
DOI: 10.7554/eLife.88538
PMCID: PMC10602586

Genes

APOL1
CTSA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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