Article
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.
Critical care (London, England) - 17 Sept 2021
Guirgis Faheem W, Black Lauren Page, Henson Morgan, Labilloy Guillaume, Smotherman Carmen, Hopson Charlotte, Tfirn Ian, DeVos Elizabeth L, Leeuwenburgh Christiaan, Moldawer Lyle, Datta Susmita, Brusko Todd M, Hester Alexis, Bertrand Andrew, Grijalva Victor, Arango-Esterhay Alexander, Moore Frederick A, Reddy Srinivasa T
Abstract excerpt
OBJECTIVE: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity. DESIGN: Prospective cohort study with independent replication cohort. SETTING:...
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