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Pharmacogenomic variants affecting efficacy and toxicity of statins in a south Asian population from Sri Lanka.

Pharmacogenomics - 1 Oct 2023

Ranasinghe Priyanga, Sirisena Nirmala, Ariadurai Jeremy N, Vishnukanthan Thuwaragesh, Thilakarathne Sathsarani, Anandagoda Gayani, Dissanayake Vajira Hw

Abstract excerpt

Aim: To describe the diversity of pharmacogenetic variants of statins among Sri Lankans. Materials & methods: Variant data of relevant genes were obtained from an anonymized database of 426 Sri Lankans. Minor allele frequencies (MAFs) were compared with published data from other populations. Results: The MAF of SLCO1B1*5 (rs4149056 [T>C]) was 18.19% (95% CI: 14.53-21.85). MAFs of CYP2C9*2 (rs1799853 [C>T]) and...

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PMID: 37877238
DOI: 10.2217/pgs-2023-0149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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