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Article

Frequency of pharmacogenomic variants affecting safety and efficacy of immunomodulators and biologics in a South Asian population from Sri Lanka.

Human genomics - 27 Sept 2024

Ranasinghe Priyanga, Liyanage Chiranthi, Sirisena Nirmala, Liyanage Sandamini, Priyadarshani C D Nelanka, Hendalage D P Bhagya, Dissanayake Vajira H W

Abstract excerpt

BACKGROUND: Immunomodulators are important for management of autoimmune diseases and hematological malignancies. Significant inter-individual variation in drug response/reactions exists due to genetic polymorphisms. We describe frequency of identified genetic polymorphisms among Sri Lankans. METHODS: Sri Lankan data were obtained from an anonymized database of 670 participants. Data on variants and global...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39334333
DOI: 10.1186/s40246-024-00674-w
PMCID: PMC11438298

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