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Article

Pharmacogenomic variants affecting efficacy and safety of medicines acting on central nervous system among Sri Lankans.

Pharmacogenomics - 1 Jan 2025

Ranasinghe Priyanga, Peiris Charindie, Jeyapragasam Hajanthy, Sirisena Nirmala D, Hendalage D P Bhagya, Dissanayake Vajira H W

Abstract excerpt

BACKGROUND: Ensuring the efficacy and safety of medicines acting on the central nervous system (CNS) remains a challenge due to their complex pharmacokinetics and inter-individual variability in response. We describe the frequencies of pharmacogenomic variants affecting CNS drug metabolism in a Sri Lankan population. METHODS: Pharmacogenomic data pertaining to genes of interest were obtained from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40944712
DOI: 10.1080/14622416.2025.2558498
PMCID: PMC12582073

Genes

CYP2B6
CYP2C19
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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