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Diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans.

Pharmacogenomics - 1 Nov 2022

Ranasinghe Priyanga, Sirisena Nirmala, Senadeera Vidarsha, Anandagoda Gayani, Dissanayake Vajira Hw

Abstract excerpt

Aims: To describe the diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans. Materials & methods: Genotype data were filtered out from an anonymized database of 400 Sri Lankans, and minor allele frequencies (MAF) were calculated. Variants of CYP2C9, VKORC1 and CYP4F2 genes were studied. Results: Overall, CYP2C9*2 and CYP2C9*3 alleles had MAFs of 2.25% (95% CI: 0.80-3.70) and 10.38%...

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Identifiers

PMID: 36285665
DOI: 10.2217/pgs-2022-0026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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