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Article

CYP2C19 and CES1 gene variants affecting clopidogrel metabolism in a South Asian population from Sri Lanka.

Pharmacogenomics - 1 Jan 2024

Ranasinghe Priyanga, Gunarathna Pulasthi B, Jeyapragasam Hajanthy, Sirisena Nirmala, Hendalage D P Bhagya, Dissanayake Vajira H W

Abstract excerpt

AIMS: Clopidogrel exhibits substantial variability in therapeutic response, largely contributed by genetic factors. The pharmacogenomic variants data on clopidogrel metabolism in South Asians have been sparsely studied. This study explores the impact of CYP2C19 and CES1 gene variants on clopidogrel metabolism in Sri Lankans, revealing significant pharmacogenomic insights with broader implications for South...

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Share to Carboxylic Ester Hydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

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Share to Platelet Aggregation Inhibitors

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Source

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Identifiers

PMID: 39809701
DOI: 10.1080/14622416.2025.2452835
PMCID: PMC11901400

Genes

CES1
CYP2C19
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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