Article
Highly improved acarbose production of Actinomyces through the combination of ARTP and penicillin susceptible mutant screening.
World journal of microbiology & biotechnology - 1 Jan 2017
Ren Fei, Chen Long, Tong Qunyi
Abstract excerpt
Atmospheric and room temperature plasma (ARTP) was first employed to generate mutants of Actinomyces JN537 for improving acarbose production. To obtain higher acarbose producing strains, the method of screening the strains for susceptibility to penicillin was used after treatment with ARTP. The rationale for the strategy was that mutants showing penicillin susceptibility were likely to be high acarbose producers,...
Topics
- Acarbose
- Actinomyces
- Atmosphere
- Cell Wall
- Genes, Fungal
- Genetic Enhancement
- Glycoside Hydrolase Inhibitors
- Hydrogen-Ion Concentration
- Mutation
- Penicillins
- Plasma Gases