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The DNA damage induced immune response: Implications for cancer therapy

3 Oct 2022

Abstract excerpt

Genomic instability is a hallmark of tumourigenesis, influencing tumour development and progression. In particular, defects in the DNA damage response (DDR) have been extensively investigated and are known to shape therapeutic response. Since immune checkpoint blockade (ICB) therapy has been approved for treatment of tumours with defective mismatch repair the interplay between DDR pathway deficiency and the...

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PMID: 36308822
DOI: 10.1016/j.dnarep.2022.103409

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