The effect of genetic polymorphisms of RARA gene on the adverse effects profile of isotretinoin-treated acne patients.

doi:10.5414/CP201874

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Article

The effect of genetic polymorphisms of RARA gene on the adverse effects profile of isotretinoin-treated acne patients.

International journal of clinical pharmacology and therapeutics - 1 Aug 2013

Alzoubi Karem H, Khabour Omar F, Hassan Razan E, Qarqaz Feras, Al-Azzam Sayer, Mhaidat Nizar

Abstract excerpt

OBJECTIVE: Isotretinoin is a vitamin A-derived medication that is associated with significant adverse effects including arthralgia/ myalgia, nose bleeds, headache, dyslipidemia, liver dysfunction and depression. The mechanism for development of such adverse effects remains elusive, and it is not known why adverse effects develop only in some patients. In this study, we examined the association between rs9303285,...

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PMID: 23782583
DOI: 10.5414/CP201874

Genes

RARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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