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Article

Cell population growth kinetics in the presence of stochastic heterogeneity of cell phenotype.

Journal of theoretical biology - 7 Nov 2023

Wang Yue, Zhou Joseph X, Pedrini Edoardo, Rubin Irit, Khalil May, Taramelli Roberto, Qian Hong, Huang Sui

Abstract excerpt

Recent studies at individual cell resolution have revealed phenotypic heterogeneity in nominally clonal tumor cell populations. The heterogeneity affects cell growth behaviors, which can result in departure from the idealized uniform exponential growth of the cell population. Here we measured the stochastic time courses of growth of an ensemble of populations of HL60 leukemia cells in cultures, starting with...

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PMID: 37863423
DOI: 10.1016/j.jtbi.2023.111645

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