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Article

A novel multiscale framework for delineating cancer evolution from subclonal compositions.

Journal of theoretical biology - 7 Apr 2024

Yao Zhihao, Jin Suoqin, Zhou Fuling, Wang Junbai, Wang Kai, Zou Xiufen

Abstract excerpt

OBJECTIVE: Owing to the heterogeneity in the evolution of cancer, distinguishing between diverse growth patterns and predicting long-term outcomes based on short-term measurements poses a great challenge. METHODS: A novel multiscale framework is proposed to unravel the connections between the population dynamics of cancer growth (i.e., aggressive, bounded, and indolent) and the cellular-subclonal dynamics of...

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PMID: 38307450
DOI: 10.1016/j.jtbi.2024.111743

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