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Article

Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug.

PloS one - 1 Jan 2021

Seita Akihisa, Nakaoka Hidenori, Okura Reiko, Wakamoto Yuichi

Abstract excerpt

Cancer cell populations consist of phenotypically heterogeneous cells. Growing evidence suggests that pre-existing phenotypic differences among cancer cells correlate with differential susceptibility to anticancer drugs and eventually lead to a relapse. Such phenotypic differences can arise not only externally driven by the environmental heterogeneity around individual cells but also internally by the intrinsic...

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Identifiers

PMID: 33524064
DOI: 10.1371/journal.pone.0236534
PMCID: PMC7850478

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