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SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.

Carcinogenesis - 12 Feb 2024

Rajanala Sai Harisha, Plym Anna, Vaselkiv Jane B, Ebot Ericka M, Matsoukas Konstantina, Lin Zhike, Chakraborty Goutam, Markt Sarah C, Penney Kathryn L, Lee Gwo-Shu M, Mucci Lorelei A, Kantoff Philip W, Stopsack Konrad H

Abstract excerpt

Solute carrier organic anion (SLCO) transporters (OATP transporters) are involved in cellular uptake of drugs and hormones. Germline variants in SLCO1B3 and SLCO2B1 have been implicated in prostate cancer progression and therapy response, including to androgen deprivation and statin medications, but results have appeared heterogeneous. We conducted a cohort study of five single-nucleotide polymorphisms (SNPs) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37856781
DOI: 10.1093/carcin/bgad075
PMCID: PMC10859730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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