Article
Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2021
Tang Li, Zhu Qianqian, Wang Zinian, Shanahan Clayton M, Bensen Jeannette T, Fontham Elizabeth T H, Smith Gary J, Pop Elena A, Azabdaftari Gissou, Mohler James L, Wu Yue
Abstract excerpt
BACKGROUND: Androgen receptor signaling is crucial to prostate cancer aggressiveness. Members of the solute carrier family of the organic anion transporting peptides (SLCO) are potential regulators of androgen availability in prostate tissue. It remains unknown whether genetic variations in SLCOs contribute to the differences in prostate cancer aggressiveness in African Americans (AA) and European Americans (EA)....
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