Article
Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2016
Wang Xiaodong, Harshman Lauren C, Xie Wanling, Nakabayashi Mari, Qu Fangfang, Pomerantz Mark M, Lee Gwo-Shu Mary, Kantoff Philip W
Abstract excerpt
PURPOSE: To validate the association of three previously demonstrated SLCO2B1 germline variants with time to progression (TTP) in patients receiving androgen-deprivation therapy (ADT), and to evaluate if the SLCO2B1 genetic variants impacted overall survival (OS) for prostate cancer (PC). PATIENTS AND METHODS: Three single nucleotide polymorphisms (SNPs), exonic SNP rs12422149 and intronic SNPs rs1789693 and...
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