Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer.

doi:10.1158/1078-0432.CCR-16-2245

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Article

Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Mostaghel Elahe A, Cho Eunpi, Zhang Ailin, Alyamani Mohammad, Kaipainen Arja, Green Sean, Marck Brett T, Sharifi Nima, Wright Jonathan L, Gulati Roman, True Lawrence D, Loda Massimo, Matsumoto Alvin M, Tamae Daniel, Penning Trevor N, Balk Steven P, Kantoff Phillip W, Nelson Peter S, Taplin Mary-Ellen, Montgomery R Bruce

Abstract excerpt

Purpose: Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo transport by SLCO-encoded transporters and that SLCO gene variation may influence intracellular abiraterone levels and outcomes.Experimental Design: Steroid and...

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Identifiers

PMID: 28389510
DOI: 10.1158/1078-0432.CCR-16-2245
PMCID: PMC5559332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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