Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2011

Wright Jonathan L, Kwon Erika M, Ostrander Elaine A, Montgomery R Bruce, Lin Daniel W, Vessella Robert, Stanford Janet L, Mostaghel Elahe A

Abstract excerpt

BACKGROUND: Metastases from men with castration-resistant prostate cancer (CRPC) harbor increased tumoral androgens versus untreated prostate cancers. This may reflect steroid uptake by OATP (organic anion transporting polypeptide)/SLCO transporters. We evaluated SLCO gene expression in CRPC metastases and determined whether prostate cancer outcomes are associated with single nucleotide polymorphisms (SNP) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasm Recurrence, Local
Share to Orchiectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organic Anion Transporters

Share to Organic Anion Transporters, Sodium-Independent

Share to Prostatic Neoplasms

Share to SEER Program

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 21266523
DOI: 10.1158/1055-9965.EPI-10-1023
PMCID: PMC3073610

Genes

IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes.PMID 21266523Read ↗

Polymorphisms of the androgen transporting gene SLCO2B1 may influence the castration resistance of prostate cancer and the racial differences in response to androgen deprivation.Semantic proximity Read ↗

SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.Semantic proximity Read ↗

Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of ProgressionSemantic proximity Read ↗

Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans.Semantic proximity Read ↗

Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer.Semantic proximity Read ↗

SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.Semantic proximity Read ↗

Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer.Semantic proximity Read ↗

Effect of <i>SLCO1B3</i> Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic CancerSemantic proximity Read ↗

Abiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3pSemantic proximity Read ↗

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.Semantic proximity Read ↗

Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.Semantic proximity Read ↗

The influence of single-nucleotide polymorphisms on overall survival and toxicity in cabazitaxel-treated patients with metastatic castration-resistant prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.