Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Challenges in undertaking nonlinear Mendelian randomization

16 Oct 2023

Abstract excerpt

Mendelian randomization (MR) is a widely used method that exploits the unique properties of germline genetic variation to strengthen causal inference in relationships between exposures and outcomes. Nonlinear MR allows estimation of the shape of these relationships. In a previous paper, the authors applied linear and nonlinear MR to estimate the effect of BMI on mortality in UK Biobank, providing evidence for a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Genetic Associations and Epidemiology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37845826
DOI: 10.1002/oby.23927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Challenges in undertaking nonlinear Mendelian randomizationPMID 37845826Read ↗

Methodological challenges in mendelian randomization.Semantic proximity Read ↗

A Guide to Understanding Mendelian Randomization StudiesSemantic proximity Read ↗

Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application.Semantic proximity Read ↗

Re-evaluating the robustness of Mendelian randomisation to measurement errorSemantic proximity Read ↗

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?Semantic proximity Read ↗

Understanding the assumptions underlying Mendelian randomization.Semantic proximity Read ↗

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization AnalysesSemantic proximity Read ↗

Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analysesSemantic proximity Read ↗

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants.Semantic proximity Read ↗

Linear and Nonlinear Mendelian Randomization Analyses of the Association Between Diastolic Blood Pressure and Cardiovascular Events: The J-Curve Revisited.Semantic proximity Read ↗

Modelling time-varying genetic effects on binary disease risk via functional Mendelian randomization.Semantic proximity Read ↗

The use of two-sample methods for Mendelian randomization analyses on single large datasets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.