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Article

Linear and Nonlinear Mendelian Randomization Analyses of the Association Between Diastolic Blood Pressure and Cardiovascular Events: The J-Curve Revisited.

Circulation - 2 Mar 2021

Arvanitis Marios, Qi Guanghao, Bhatt Deepak L, Post Wendy S, Chatterjee Nilanjan, Battle Alexis, McEvoy John W

Abstract excerpt

BACKGROUND: Recent clinical guidelines support intensive blood pressure treatment targets. However, observational data suggest that excessive diastolic blood pressure (DBP) lowering might increase the risk of myocardial infarction (MI), reflecting a J- or U-shaped relationship. METHODS: We analyzed 47 407 participants from 5 cohorts (median age, 60 years). First, to corroborate previous observational analyses, we...

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Identifiers

PMID: 33249881
DOI: 10.1161/CIRCULATIONAHA.120.049819
PMCID: PMC7920937

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