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Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases

1 Jun 2013

Abstract excerpt

Constant oxygen supply is essential for proper tissue development, homeostasis and function of all eukaryotic organisms. Cellular response to reduced oxygen levels is mediated by the transcriptional regulator hypoxia-inducible factor-1 (HIF-1). It is a heterodimeric complex protein consisting of an oxygen dependent subunit (HIF-1α) and a constitutively expressed nuclear subunit (HIF-1β). In normoxic conditions,...

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PMID: 23701276
DOI: 10.2174/13894501113149990015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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