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The Role of Hypoxia-Inducible Factor in the Mechanisms of Aging

1 Sept 2022

Abstract excerpt

Aging is accompanied by a reduction in the oxygen delivery to all organs and tissues and decrease in the oxygen partial pressure in them, resulting in the development of hypoxia. The lack of oxygen activates cell signaling pathway mediated by the hypoxia-inducible transcription factor (HIF), which exists in three isoforms - HIF-1, HIF-2, and HIF-3. HIF regulates expression of several thousand genes and is a...

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PMID: 36180993
DOI: 10.1134/s0006297922090115

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