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Article

Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

Cell death & disease - 1 Dec 2016

Andresen Vibeke, Erikstein Bjarte S, Mukherjee Herschel, Sulen André, Popa Mihaela, Sørnes Steinar, Reikvam Håkon, Chan Kok-Ping, Hovland Randi, McCormack Emmet, Bruserud Øystein, Myers Andrew G, Gjertsen Bjørn T

Abstract excerpt

Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog. The NPM1-mutated cell line OCI-AML3 and normal karyotype primary AML cells with...

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Source

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Identifiers

PMID: 27906185
DOI: 10.1038/cddis.2016.392
PMCID: PMC5260983

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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