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Article

⁹⁹mTc-HYNIC-MPG: a novel SPECT probe for targeting mutated EGFR.

Bioorganic & medicinal chemistry letters - 1 Apr 2015

Yan Yan, Xiao Zun-Yu, Song Yan, Kang Zhao-Ting, Wang Ping, Sun Xi-Lin, Shen Bao-Zhong

Abstract excerpt

Mutated epidermal growth factor receptor (EGFR) is an important biomarker for cancer diagnosis and molecular target for many anticancer drugs. Localizing EGFR and evaluating EGFR mutational status can help to identify patients who are potentially the most suitable ones for targeted treatments. Hence, we developed a novel EGFR tyrosine kinase inhibitor labeled with (99m)Tc ((99m)Tc-HYNIC-MPG) and evaluated its...

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Source

Identifiers

PMID: 25716904
DOI: 10.1016/j.bmcl.2014.12.074

Genes

EGFR
MPG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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