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Article

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

1 Jan 2023

Abstract excerpt

Abstract Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma. Previous studies have shown that the knockdown of ERN1 (endoplasmic reticulum to nucleus signaling) significantly suppressed the glioblastoma cell proliferation and modified the hypoxia regulation. The present study is aimed to investigate the impact of...

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Share to Autophagy in Disease and Therapy
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PMID: 37823569
DOI: 10.2478/enr-2023-0028

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