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Article

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

26 Feb 2019

Abstract excerpt

BACKGROUND: HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling and HIF1A does not show clinical efficiency because of changeable oxygen concentrations in solid tumor areas. The identification of HIF1A targets expressed in both normoxia and hypoxia and of HIF1A/hypoxia signatures might...

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PMID: 30808328
DOI: 10.1186/s12881-019-0767-1

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