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Article

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis

1 Feb 2019

Abstract excerpt

Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic...

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PMID: 30811976
DOI: 10.1016/j.celrep.2019.01.106

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