Integrated Genomic Profiling of PTEN and TP53 in Cervical Neuroendocrine Carcinoma: Synergistic Roles With HER2/KRAS/PIK3CA and Implications for Precision Oncology.

doi:10.1002/gcc.70173

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Integrated Genomic Profiling of PTEN and TP53 in Cervical Neuroendocrine Carcinoma: Synergistic Roles With HER2/KRAS/PIK3CA and Implications for Precision Oncology.

Genes, chromosomes & cancer - 1 Sept 2026

Shen Huang-Pin, Lee Ming-Yung, Lee Yi-Ju, Chen An-Chi, Chen Chi-Kuan, Chao Wan-Ru, Han Chih-Ping

Abstract excerpt

BACKGROUND: Neuroendocrine carcinoma (NEC) of the uterine cervix is a rare, highly aggressive malignancy with a poor prognosis. Expanding upon our previous work, which identified frequent mutations in HER2, KRAS, and PIK3CA in this disease, we sought to refine the genomic landscape by characterizing alterations in TP53 and PTEN, and their relationships with these oncogenic drivers. METHODS: Genomic DNA from 12...

Read the complete abstract on PubMed

Topics

Humans
PTEN Phosphohydrolase
Female
Tumor Suppressor Protein p53
Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Erb-b2 Receptor Tyrosine Kinases

Uterine Cervical Neoplasms

Proto-Oncogene Proteins p21(ras)

Carcinoma, Neuroendocrine

Mutation

Precision Medicine

Phosphatidylinositol 3-Kinases

Source

Open in PubMed

Identifiers

PMID: 42765697
DOI: 10.1002/gcc.70173

Genes

PTEN
TP53
KRAS
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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