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Article

Unlocking the role of the B7-H4 polymorphism in psoriasis: Insights into methotrexate treatment outcomes: A prospective cohort study.

Immunology - 1 Jan 2024

Wang Bing, Wang Zhicheng, Yang Wenjing, Han Ling, Huang Qiong, Yawalkar Nikhil, Zhang Zhenghua, Yao Yu, Yan Kexiang

Abstract excerpt

B7-H4 is a recently discovered member of B7 family that negatively regulates T-cell immunity, specifically Th1 and Th17 cell responses. However, its role in the pathogenesis of psoriasis has yet to be determined. This study aims to investigate the effect of B7-H4 polymorphism on the efficacy of methotrexate (MTX) and its mechanism in psoriasis. Four single nucleotide polymorphisms of B7-H4 were genotyped in 310...

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PMID: 37814391
DOI: 10.1111/imm.13704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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