Article
Genetic Polymorphisms of rs9949644 in MAPK4 Are Associated with Clinical Response to Methotrexate in Patients with Psoriasis.
Dermatology (Basel, Switzerland) - 1 Jan 2024
Fan Zhijia, Huang Qiong, Zhang Zhenghua, Han Ling, Fang Xu, Yang Ke, Huang Guiqin, Zheng Zhizhong, Yawalkar Nikhil, Lin Yong, Wang Zhicheng, Yan Kexiang
Abstract excerpt
BACKGROUND: The study aimed to investigate the relationship of MAPK4 genetic variants with the efficacy of methotrexate (MTX) in psoriasis patients. METHODS: Patients treated with MTX were classified as responders or nonresponders if the Psoriasis Area and Severity Index (PASI) at week 12 was reduced to greater than 75% or lower than 75%, respectively. The genotypes of 14 MAPK4 single-nucleotide polymorphisms in...
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